2016 Mercedes-Benz E-Class Fuel Economy

EPA ratings by trim

City and highway are EPA's adjusted label figures; combined is the 55/45 blend printed on the window sticker. For electric and plug-in trims the MPG columns are MPGe, and the kWh per 100 miles is the figure a charging cost actually turns on; EPA measures it at the wall, so charging losses are already in it. Unrounded combined figures, where EPA publishes them: AMG E63 4matic 18.5771; AMG E63 S 4matic 17.7084; AMG E63 S 4matic (wagon) 17.7098; E350 23.4253; E350 23.2863; E350 4matic 23.0555; E350 4matic 23.0555; E350 4matic (wagon) 22.3889; E400 23.4941; E400 4matic 22.4692; E400 4matic Coupe 22.836; E400 Convertible 23.4414; E400 Coupe 23.4298; E550 4matic 20.5817; E550 Convertible 20.1288; E550 Coupe 20.6651.

What the rating costs per mile

The rating divided by a price, times your miles. It starts at EIA's current U.S. averages and EPA's 15,000 miles so the right-hand column is comparable; type your own pump price, home rate and mileage over them.

Fuel only — before depreciation, insurance, maintenance or tires, which the True Cost per Mile Calculator adds. Most drivers land below the rating; the True MPG Calculator measures your own from two fill-ups.

EPA's own figures, and why they differ

The “EPA's figure” column is EPA's annual fuel cost from the same file: 15,000 miles, 55% city, and the national fuel price fueleconomy.gov was using on the day the file was built (2026-09-29). fueleconomy.gov recomputes its page every week at the current price, so its number and the file's drift apart between file dates; the middle columns here use a price you can see and change, which is the only honest way to compare two cars. EPA also prints a five-year “you save/spend” against the average new vehicle (spends $5,750 for the E350); it rests on the same assumptions and is not repeated here as a result.

Every figure on this page is a rating, not a measurement of any particular car. The site never calls a rating wrong; it shows what your own price and miles do to it. See the model on fueleconomy.gov.

Other model years of the Mercedes-Benz E-Class: 2027, 2026, 2025, 2024, 2023, 2022, 2021, 2020, 2019, 2018, 2017, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999, 1998, 1997, 1996, 1995, 1994.